UD’s research core facilities—high-tech instruments that are shared resources, supporting studies across campus—are available to UD faculty and their collaborators.
Increasingly, these sophisticated facilities are becoming critical state, national and international assets, supporting projects and programs of student and public benefit, including federally funded national centers of excellence.
NOTE: Core facilities reporting to Research Office
LOCATED IN: Interdisciplinary Science and Engineering Laboratory
Core FacilityOVERVIEW: The University of Delaware’s Advanced Materials Characterization Lab is centrally located on the ground floor of the Interdisciplinary Science and Engineering building. This provides the opportunity and setting for the exchange of novel ideas and science for the next generation. Located in the same building are the multidisciplinary classrooms for undergraduate education continuing the theme of the multidisciplinary approach.
Phillips Xpert Powder X-ray Diffractometer
Rigaku Miniflex Powder X-ray Diffractometer
Rigaku Ultima 4 Multipurpose X-ray Diffractometer
Bruker D8 Multipurpose X-ray Diffractometer
Phillip SAXS small angle Diffractometer
T/A Instruments DSC,DTA,TGA,DMA,DTC
Metrohm IC Pro Chromatograph
Agilent HPLC 1260 /MS 6120
Agilent Cary UV Vis Spectrometer
Kaiser 785nm Raman Spectrometer
Wyatt Dynamic Light Scattering
Beckman Coulter LS13 320 Particle Analyzer
Micromeritics Porosity Analyzer
Agilent ICP/MS 7500
Agilent AES 4100 Mass Spec.
Provide short courses on all instrumentation on a regular basis.
Core Facility and CenterOVERVIEW: Providing scientific expertise and core infrastructure support in Bioinformatics and Computational Biology for the Delaware research and education community. Available resources include bioinformatics services, consulting, training and access to computational infrastructure and software.
Center, Core Facility and CenterOVERVIEW: Serving researchers campus-wide, statewide and throughout the region, the CBBI will advance research on psychopathology, cancer, stroke, cerebral palsy, osteoporosis and other diseases and disorders.
Core FacilityOVERVIEW: The Center for Human Research Coordination (CHRC) is a core research facilities at UD dedicated to support each college, institute and center.
Building on the accomplishments of the Delaware Rehabilitation Institute, CHRC helps to streamline the process of recruiting, screening and registering research participants and developing data management resources for studies underway across the University.
Core FacilityOVERVIEW: The Comparative Pathology Laboratory provides histology and pathology support for animal diagnostic laboratories of Delaware and Maryland, researchers at the University of Delaware and its affiliates (DBI, etc.), industry and government partners of the university, and external researchers. We specialize in animal tissues and studies related to animal disease or animal models of human disease. However, we also routinely accept plant specimens for tissue processing. We strive to provide clients with customized high quality specimen preparations and thorough pathology reports to meet their individual diagnostic and research needs.
Histology Services: Tissue preparation including trimming, processing, paraffin embedding and microtomy, automated H&E staining, manual special staining upon request (i.e. Gram, Masson’s trichrome, etc.)
Consultation and equipment training upon request:
Pathology Services: Microscopic analysis of tissues for diagnostic cases and research studies, consultation on experimental design, necropsy, and specimen collection and preparation, digital photography of gross or histologic specimens.
LOCATED IN: Fischer Greenhouse Complex (Sq. ft.: ~ 33,600)
Core FacilityOVERVIEW: A state-of-the-art plant growth facility in the University of Delaware College of Agriculture and Natural Resources, the Fischer Greenhouse Complex is a professionally-managed suite of growth chambers and glass house facilities serving the research and education community.
The Fischer Greenhouse Complex provides the primary greenhouse space available to faculty, professionals, staff and students, and is dedicated to the acquisition and dissemination of knowledge through research, teaching and outreach activities, extension demonstrations, departmental functions, and sponsored student organizations.
The 13,800 ft2 Fischer Greenhouse Complex and the Growth Chamber Facilities offers:
Glass houses (17,000 ft2) with headhouse (5,000 ft2)
Growth chambers (2,300 ft2 ) and growth room (500 ft2)
Core FacilityOVERVIEW: The goals of the High Throughput Experimentation (HTE) Center at the University of Delaware are to enable high throughput chemical experimentation, including compound library synthesis, reaction development, and collection of data sets for statistical model development. We seek to do to this through the use of our extensive library of chiral and achiral ligands, automated and manual tools for reaction set-up, and analytical instrumentation for detection of products with a range of molecular weights, stabilities, and polarities. Initially funded by a UNIDEL grant received by Dr. Don Watson and Dr. Mary Watson, we are currently in the pilot phase for this lab and actively working to recruit new users and implement a charging model. Please feel free to reach out if you have any questions about using or collaborating with our facility.
Design, running, and analysis of 24- and 96-well plates, including for:
– Ligand screening
– Reaction optimization
– Library synthesis
LC-MS, SFC-MS, and GC-FID method development
LC-MS, SFC-MS, GC-FID, and GC-MS analysis
Training on facility instrumentation and on running HTE plates should be requested through iLab.
ADDRESS: 110 Lammot duPont Laboratory, Newark, DE 19716
LOCATED IN: Lammot duPont Laboratory
Core FacilityOVERVIEW: The core facility is grouped into three areas; the first laboratory houses the high performance instruments for more detailed and precise analyses, a second lab houses three open-access, user-friendly instruments that are available for researchers to use 24/7, and finally, a high-performance MALDI instrument is located in Murray V. Johnston’s Lab.
High-Performance Instrumentation Lab (Room 122, Lammot duPont Lab), Protein Sequencing, Micromass model Ultima Q Tof (Quadrupole-Time of Flight tandem mass spectrometer): This is an LC-MS-MS instrument primarily used to identify proteins by sequencing the products of a digested protein. Product molecular ions and subsequent collisional activation to generate fragments are automatic. Software generated or de novo peptide sequencing can be compared to protein databases for identification.
Protein Digester- Bruker Daltonics model Proteineer DP: This automated digest and prep station performs protein digests. Digest products can be automatically spotted to a MALDI sample plate or captured in MTP format for LC-MSMS analyses.
Open Access Instrumentation Lab (Room 108, Lammot duPont Lab)
GC-MS (Gas Chromatography-Mass Spectrometry): Agilent models 6850 GC and 5973 MS with autosampler. Used primarily for separation of small organic mixtures, incorporates a NIST library to aid identification.
LC-MS (Liquid Chromatography-Mass Spectrometry): Thermo-Finnigan model LCQ using Electrospray Ionisation (ESI) with an integrated autosampler. Used for biological samples and polar organics. The instrument can be switched between column mode for mixture separations and loop injections for quick analyses of purer samples.
MALDI (Matrix Assisted Laser Desorption Ionisation) Bruker Daltonics model Omniflex: Used primarily for biological samples to determine molecular weight and purity.
Murray V. Johnston Lab (Room 125, Lammot duPont Lab)
MALDI- Bruker Daltonics model Biflex MALDI mass spectrometer: Used for high-resolution and accurate mass measurements; automated protein identification via peptide mass maps.
High-resolution accurate mass measurement (HRMS) of organic and organometallic compounds using Waters GCT Premier equipped with Electron Impact (EI), Chemical Ionization (CI), Desorption Chemical Ionization (DCI), Field Ionization (FI), Field Desorption (FD) and Liquid Injection Field Desorption Ionization (LIFDI).
LC/MS and LC/MS/MS using Shimadzu LCMS 2020, Waters Q-TOF and Thermo Q-Exactive Orbitrap with Electrospray Ionization (ESI) and Atmospheric Pressure Chemical Ionization (APCI).
GC-MS (low-resolution EI only) using the Agilent 5973 system.
MALDI analysis of proteins, oligonucleotides, nanoparticles, synthetic polymers and macromolecules.
Mass directed prep purification is also available.
Core FacilityOVERVIEW: The Nuclear Magnetic Resonance (NMR) Facility currently has six NMR spectrometers. The NMR facilities are located in the basement floor of the North Wing of Brown Laboratories (BRL). The 600 MHz instrument is housed in 015 BRL and the remaining spectrometers are located across the hallway in three adjacent rooms (011, 011A and 021 BRL).
Two solution 400 MHz NMR spectrometers, one with an auto-sampler and a cryogenic QNP probe and another with multinuclear capabilities, are available for routine proton and multinuclear NMR analysis of organic and inorganic materials. Also: two solution 600 MHz spectrometers, one with a triple-resonance cryogenic probe for biomolecular samples and another with an auto-sampler and enhanced 19F capabilities for expanded NMR applications such as high-resolution magic angle spinning (HRMAS) for semi-solid materials.
The 500 MHz solid-state NMR spectrometer is currently equipped with a 3.2 mm triple-resonance (1H, 13C and 15N) probe for biosolids and other organic solid material. The 850 MHz spectrometer is hybridized for both solution and solid-state NMR measurements. With the ultra-high magnetic field and a large collection of solution and solid-state NMR probes, the 850 MHz NMR spectrometer covers a broad range of applications from inorganic material, synthetic organic polymeric materials to structure and dynamic studies in structural biology.
In addition to the departmental NMR instrument, four NMR spectrometers with frequencies ranging from 200 to 600 MHz are used and maintained by the following research groups: Polenova, Dybowski and Rozovsky. Most of these spectrometers are dedicated solid-state NMR instruments.
Liquid-state NMR spectroscopy
Bruker AM-250 spectrometer (Tecmag Upgrade) (011 BRL) 5mm, Dual probe for 1H and 13C measurements
Bruker AC-250 spectrometer (Tecmag Upgrade) (011 BRL), 5mm Dual probe for 1H and 13C measurements, 5mm Proton-only probe, Variable Temperature Unit available
Dell Precision workstation (Linux Redhat 7.5 and Bruker xwinnmr 3.5) for off-line data processes
Traditionally, the institutional support made a primary contribution to the operational budget of NMR laboratory. A user-fee structure has been established to offset the increasing expenses of maintaining the expanded NMR laboratory in terms of the number of instruments and users. The COBRE III has been providing significant contribution to the NMR laboratory operational budget. To all federally funded investigators: please acknowledge the NIH support of this COBRE-sponsored core in all your publications where you utilized the NMR core. The language for the acknowledgment can be found in a COBRE citation webpage.
Core FacilityOVERVIEW: The Surface Analysis Facility exists primarily to support the federally funded research projects of University of Delaware faculty members, and it has been subsidized from University sources to do so. To help defray operating costs, the Facility also welcomes, and the NSF encourages, collaborative interactions with other universities and colleges, as well as local, regional and national for-profit companies.
IONTOF TOF.SIMS 5 system
Thermo Scientific K-Alpha XPS system
Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS)
Core FacilityOVERVIEW: The X-ray Crystallography Laboratory conducts characterizations by X-ray diffraction of small-molecule organic or inorganic single crystals. As an extension service, the facility also accepts sample submissions from other departments of the University and from local, national and international collaborators of academe and industry. The facility also serves as an ancillary graduate research laboratory for selected graduate students pursuing studies in inorganic chemistry leading to a doctorate degree.
Dual wavelength APEX II Duo (Mo & Cu) Bruker-AXS CCD X-ray diffractometer. Data are collected typically at 200K. Structures are solved with SHELXTL software.
Typical turnaround times under average conditions, from start of data-collection to completely refined structure, range from a few hours to a day.
ADDRESS: 100 Discovery Blvd, STAR TOWER, 6th Floor, Newark, DE 19710
Core FacilityOVERVIEW: The College of Health Sciences Biostatistics Core supports the development, conduct, and dissemination of research conducted in the College of Health Sciences and across the University of Delaware. In addition to CHS faculty researchers, we also support the development of student researcher through teaching graduate level courses student and mentorship. The work of the Biostatistics Core is critical for research progress in the College, which is ranked highly in terms of funding received from the National Institutes of Health for Schools of Allied Health. The Core supports a wide portfolio of externally-funded projects including R01s, R21s, the ACCEL-Center for Translational Research, and the Center for Biomedical Research Excellence in Cardiovascular Health (COBRE). Our statisticians are collaborators and an integral part of research teams and typically serve as funded personal on grant proposals. As such, they help shape the direction of research by providing methodological expertise that can improve science, build stronger teams, and lead to more competitive proposals for external funding.
The Biostatistics Core partners with Principal Investigators on the development of Specific Aims, Research Questions, and Hypotheses; advises on research design; and provides power analyses and statistical analysis plans
The Biostatistics Core performs data analyses, assists Principal Investigators in the interpretation of results, and contributes to the methods, results, and discussion sections of peer-reviewed abstracts and manuscripts.
The Biostatistics Core teaches in the MPH in Epidemiology Program, offering courses to graduate students across the College of Health Sciences. In addition to formal courses, members of the Core may teach workshops and serve as mentors to individual graduate students, for example as members of a thesis or dissertation committee.
LOCATED IN: Ammon Pinizzotto Biopharmaceutical Innovation Center, Suite 141
Core Facility and CenterOVERVIEW: The BioImaging Center is a multi-user microscopy facility containing state-of-the-art electron, confocal and light microscopes. The center is open to all academic researchers on a fee-for-service basis. Outside industrial users are accommodated when scheduling permits.
We host a range of microscopes and sample preparation equipment to meet research demands.
Zeiss LIBRA 120 transmission electron microscope (TEM)
Hitachi S4700 field emission scanning electron microscope (FE-SEM)
Zeiss LSM780 spectral and high sensitivity confocal microscope
Zeiss LSM510 NLO multi-photon confocal microscope
Zeiss LSM510 DUO spectral and high-speed confocal microscope
PECON live cell incubator for the inverted confocal microscopes
INSTEC thermoelectric heating and cooling for confocal microscopes
Zeiss ELRYA PS1 super resolution microscope
Custom-built total internal reflection fluorescence microscope (TIRFM)
Veeco Nanoscope IIIA atomic force microscope (AFM)
Bruker Bioscope Catalyst AFM with integrated light microscopy
Sample Preparation equipment:
Leica EM AFS automated freeze substitution system
Leica EM PACT high-pressure freezing system
Leica EM CPC plunge freezer
Leica EM IGL automated immunogold labeler
Reichert-Jung Ultracut E microtome for ultrathin sectioning (two)
PELCO Biowave 34700 microwave tissue processor
PELCO easiGlow Glow Discharge system
Leica EM KMR2 glass knife maker
EMCorp Microcut 1200 Vibratome
Denton Bench Top Turbo III for carbon or gold/palladium coating
Autosamdri-815B critical point dryer
Dell T7500 Workstation for super resolution analysis
Dell T5500 Workstation for visualization software
VSG AMIRA 5.4 analysis and visualization software
Perkin Elmer Volocity 6.2 analysis and visualization software
SVI Huygens Pro deconvolution software
We provide full-service sample preparation, data acquisition and image processing for all imaging technologies upon request. Experienced staff members can provide training on equipment, sample preparation techniques, and image analysis.
LOCATED IN: Harker Interdisciplinary Science and Engineering (ISE) Laboratory
Core FacilityOVERVIEW: The University of Delaware Materials Growth Facility (MGF) primary objective is to provide the infrastructure, equipment, and staff support necessary to enable existing faculty, new faculty, and academic and corporate partners to undertake competitive research and development in the growing number of materials, science, and engineering fields.
The University of Delaware (UD) Materials Growth Facility (MGF) offers III-V and topological insulator (TI) growth of epitaxial semiconductor films.
These growths are performed on a dual-chamber GENxplor molecular beam epitaxy (MBE) system. Our staff offers full-service material calibration and growth, as well as training to perform MBE deposition.
The MGF is integrated into the Delaware Institute for Materials Research (DIMR), providing seamless materials growth, materials characterization, electron microscopy, and nanofabrication capabilities.
III-V MBE (APOLLO) FEATURES:
Standard III-V source materials (gallium, indium, aluminum, arsenic, antimony)
Electron beam evaporator for high-temperature materials (tungsten, molybdenum, tantalum, niobium, zirconium)
Low-flux gallium capping source
Substrate heating up to 1200 °C (sample rotation up to 60 rpm)
Sample size: small pieces to 3″ wafers
In-situ monitoring: RHEED, RGA (to 100 AMU), chamber and BFM
Load lock sample out-gassing (200 °C)
UHV MAGNETIC SPUTTERING SYSTEM (HEPHAESTUS) WILL FEATURE:
A wide range of source targets (metallic, dielectric, and precious metal)
Three high-purity gas controllers (argon, nitrogen, oxygen)
Six magnetrons (three with high strength fields for magnetic target materials)
Off-axis capability for one magnetron (for deposition of MgO based magnetic tunnel junctions)
High temperature substrate heater
The following calibrations are standard. Calibrations outside these standard calibrations may be the responsibility of the group needing them, warrant consideration as a collaborator, or eventually be included as a standard calibration.
GaAs, AlAs, and InAs growth rates
GaSb and AlSb growth rates
InGaAs lattice-matching (to InP) and growth rate
InAlAs lattice-matching (to InP) and growth rate
Silicon and beryllium doping in GaAs (generally convertible to other materials)
Tellurium doping in GaSb
Bi2Se3 growth rate
Bi2Te3 growth rate
In2Se3 growth rate
Growths utilizing our wide range of additional Capabilities can be calibrated to specific user needs or performed on a “best effort” basis.
For additional details, see our MGF Procedures or contact us (below).
The MGF stocks several wafer types which are available to users at cost.
2” GaAs (001-oriented, semi-insulating)
2” GaAs (001-oriented, n-type)
2” InP (001-oriented, semi-insulating)
2” InP (001-oriented, n-type)
1cm x 1cm c-plane sapphire
Other wafers may be used with approval
The Epitaxy Engineer can perform sample characterization, using many of the facilities available at UD. When staff-assisted time that does not involve growth on an MBE is required, user fees are set on an hourly basis.
Core FacilityOVERVIEW: The UD Nanofabrication Facility (UDNF) will enable researchers in academia, industry and government to create devices smaller than a human hair, supporting scientific advances in fields ranging from medical diagnostics to environmental sensing to solar energy harvesting. Explore our website to learn about our facility and all that we offer.
The UD Nanofabrication Facility (UDNF) has world-class capabilities in the areas of lithography, deposition, etch, thermal processing, characterization, and device packaging. Below is a comprehensive list of our equipment and fees.
UDNF will consider performing fabrication work on behalf of others. The service fee is $50/hr for UD users, $75/hr for external academic users, and $150/hr for corporate users. Please contact Iulian Codreanu for details.
UD has many additional resources that may be of interest to potential facility users. The links below will take you to additional information on other user facilities on campus. Keck Center for Advanced Microscopy & Microanalysis, Advanced Materials Characterization Laboratory, Materials Growth Facility, Delaware Biotechnology Institute.
Our Services include: Film Casting, Lithography, Deposition, Dry Etch, Thermal Processing, Metrology, Packaging and more.
Core FacilityOVERVIEW: The MakerSpace is an interdisciplinary design and fabrication studio, focused on student empowerment and collaboration. This creative space is equipped with a robust array of processes which compliment and provide depth to existing making capabilities on campus in order to support education, research, and personal growth. All students have access to our resources including the necessary training and design consultation to help them turn their ideas into action. This is everyone’s sandbox.
Ultimaker S5 FDM 3D Printers (8)
MarkForged X7 CFF 3D Printer
Universal ILS12.75 Laser Cutter
Universal PLS6.75 Laser Cutter
Omax Protomax Water Jet
Thermwood Multipurpose 45 CNC Router
Tormach M1100MX CNC Mill
Safety Speed H5 Panel Saw
SawStop Industrial 5HP Table Saw
Omga 1P 350F Miter Saw
Felder FB510 Band Saw (2)
Nova Voyager Drill Press
Powermatic 31A Combination Sander
Spindle Sander Jet JOSS-S
Juki DDL-5550N Industrial Sewing Machine (2)
Epson SureColor P9000 Standard Edition Printer
Use of the Pearson Hall MakerSpace resources is by reservation. Walk-in use is permitted provided it does not interfere with previously scheduled reservations or scheduled events.
Your reservation will not be honored if you have not fully completed the required MakerSpace training and are not authorized on that equipment.
LOCATED IN: Ammon-Pinizzotto Biopharmaceutical Innovation Center
Core Facility and CenterOVERVIEW: The University of Delaware Sequencing and Genotyping Center (SGC) supports genomics research through our established expertise with state-of-the-art genomics technologies. Our core center is located in the Delaware Biotechnology Institute, which is an interdisciplinary research unit at the University of Delaware. The SGC provides assistance with experimental design, user training, sample and data analysis. Instrumentation housed in the SGC supports high-throughput, single-molecule, and Sanger sequencing technologies, as well as qualitative and quantitative analysis of nucleic acids.
llumina HiSeq 2500
Pacific Biosciences RSII Single-Molecule Sequence
ABI Prism 3130XL Genetic Analyzer
ABI 7500 Fast Real-Time PCR System
Pippin Blue DNA Size Selection System
Covaris S2 Adaptive Focused Acoustic Disruptor with CryoPrep
ADDRESS: 250V Harker Interdisciplinary Science and Engineering Laboratory, Newark, DE 19716
LOCATED IN: Harker Interdisciplinary Science and Engineering (ISE) Laboratory
Core FacilityOVERVIEW: The W.M. Keck Center for Advanced Microscopy and Microanalysis (Keck CAMM) has been established since 2001 through generous grants from the W. M. Keck Foundation, the National Science Foundation and funds from the University of Delaware. This facility contributes to scientific capabilities by enabling students, faculty and other researchers in the University and from regional institutions and facilities to use state-of-the-art equipment for research and education.
It houses two 200 kV field emission transmission electron microscopes, Talos F200C and JEM-2010F, a LaB6 300kV TEM JEM-3010, an FEI 120kV Tecnai G2 12 Twin transmission electron microscope, two scanning electron microscopes (JSM-7400F and AURIGATM 60 CrossBeamTM with the AURIGATM 60 being a FIB-SEM dual beam instrument), and two scanning probe microscopes (Multimode NanoScope V and Dimension 3100 V).
Equipment 1 Talos F200C (200kV FE-TEM)
Equipment 2 JEM-2010F (200kV FE-TEM)
Equipment 3 JEM-3010 (300kV TEM)
Equipment 4 Tecnai G2 12 (120kV TEM)
Equipment 5 Auriga 60 CrossBeam (FIB/FE-SEM)
Equipment 6 JSM-7400F (FE-SEM)
Equipment 7 Dimension-3100 V SPM
Equipment 8 MultiMode NanoScope V SPM
The laboratory staff and associated faculty members are knowledgeable in SEM, TEM and SPM and are experts in advanced microscopy of a wide range of materials. We work with users on campus and other organizations in many areas including research, research training, and consultation.
Thriving research institutes and centers at the University of Delaware reflect the diversity and rigor of UD’s research interests and activity as well as our commitment to improving the quality of life in Delaware and beyond. Our academic landscape is shaped by these partnerships and plays a strategic role in bringing scholars and scientists together at UD.
NOTE: Institutes & Centers reporting to Research Office
Center OVERVIEW: Cardiovascular diseases (CVDs) such as coronary artery disease, heart failure, and stroke remain the number one cause of death in the U.S. for both men and women. CVDs affect Delawareans at a rate significantly above the national average. CVDs are largely preventable, and related to risk factors prevalent in the state and region such as poor diet, obesity, physical inactivity, and other modifiable behaviors. In addition to these risk factors, increasing age and the presence of other chronic conditions significantly raise the risk for cardiovascular events and death.
Ideal cardiovascular health is defined as the absence of clinically manifest CVD, along with optimal levels of blood pressure, cholesterol, blood glucose, and body weight.1 In addition, ideal cardiovascular health is associated with healthy behaviors such as regular physical activity, lack of smoking, and healthy eating patterns. It is well established that unhealthy cardiovascular behaviors can result in structural and/or functional vascular changes, causing target organ impairment and damage. More mechanistic information is needed to combat CVDs, and novel interventions need to be tested to improve cardiovascular health and overall well being.
The goal of the University of Delaware Center of Biomedical Research Excellence in Cardiovascular Health is to support multidisciplinary research aimed toward understanding the mechanisms underlying the causes and consequences of poor cardiovascular health and/or function, and developing effective interventions for these conditions.
Brachial artery flow mediated (FMD) with and without nitroglycerin
Assessment of microvascular function via laser Doppler of cutaneous circulation