imageResearch & Discovery

A Blog Devoted to UD Innovation, Excellence and Scholarship
image

Research & Discovery

A Blog Devoted to UD Innovation, Excellence and Scholarship

Deep data dive helps researchers predict spastic cerebral palsy

by | June 21, 2018

UD Professor Adam Marsh

ABOVE: The pioneering technique UD Professor Adam Marsh developed to analyze the genetic activity of Antarctic worms is proving valuable for human health care research. | Photo illustration by Jeffrey Chase

Interdisciplinary team from UD, Nemours and Genome Profiling report new findings in understanding the condition

When University of Delaware molecular biologist Adam Marsh was studying the DNA of worms living in Antarctica’s frigid seas to understand how the organisms managed to survive—and thrive—in the extremely harsh polar environment, he never imagined his work might one day have a human connection.

But it turns out that the genome of these Antarctic worms is very similar to ours in terms of the number and types of genes present. And the pioneering technique Marsh developed to analyze their genetic activity is proving valuable for human health care research.

Marsh and a business partner established a biotechnology company to make that technique available for such study. Specifically, Marsh’s method uses next-generation genetic sequencing data to measure how cells control the way genes are turned on or off, a process known as DNA methylation.

Now, a Delaware team has released a study in the peer-reviewed journal BMC Bioinformatics showing that DNA methylation patterns in circulating blood cells can be used to help identify spastic cerebral palsy (CP) patients.

UD Research on Twitter

TOP STORIES

Feng Jiao

Greener hydrogen from water

UD innovator explores catalysts that pull their weight and serve the environment

Anjana Bhat

Disruptors: Moving Forward with Autism

With skills in physical therapy, behavioral neuroscience and biomechanics, Anjana Bhat brings expansive expertise to her work developing creative therapies for those living with autism spectrum disorders.

Harsh Bais, Yan Jin, Kali Kniel

Disruptors: Harnessing Beneficial Microbes

So, what do a virologist, botanist and soil physicist have in common? This team from UD’s College of Agriculture and Natural Resources is leveraging their collective expertise to ensure that our food supply is safe and abundant, now and in the future.

Share This