imageResearch & Discovery

A Blog Devoted to UD Innovation, Excellence and Scholarship
image

Research & Discovery

A Blog Devoted to UD Innovation, Excellence and Scholarship

Deep data dive helps researchers predict spastic cerebral palsy

by | June 21, 2018

UD Professor Adam Marsh

ABOVE: The pioneering technique UD Professor Adam Marsh developed to analyze the genetic activity of Antarctic worms is proving valuable for human health care research. | Photo illustration by Jeffrey Chase

Interdisciplinary team from UD, Nemours and Genome Profiling report new findings in understanding the condition

When University of Delaware molecular biologist Adam Marsh was studying the DNA of worms living in Antarctica’s frigid seas to understand how the organisms managed to survive—and thrive—in the extremely harsh polar environment, he never imagined his work might one day have a human connection.

But it turns out that the genome of these Antarctic worms is very similar to ours in terms of the number and types of genes present. And the pioneering technique Marsh developed to analyze their genetic activity is proving valuable for human health care research.

Marsh and a business partner established a biotechnology company to make that technique available for such study. Specifically, Marsh’s method uses next-generation genetic sequencing data to measure how cells control the way genes are turned on or off, a process known as DNA methylation.

Now, a Delaware team has released a study in the peer-reviewed journal BMC Bioinformatics showing that DNA methylation patterns in circulating blood cells can be used to help identify spastic cerebral palsy (CP) patients.

UD Research on Twitter

TOP STORIES

Honors

Honors

Eight UD professors recently received the National Science Foundation’s highly competitive CAREER Award, which is given to scientists and engineers who exemplify the role of teacher-scholars through their outstanding research and teaching.

April Kloxin

UD’s April Kloxin wins NIH innovator award

Engineering professor April Kloxin receives grant to accelerate the study of lung fibrosis

engineering discover day

Engineering discovery day

High school girls learn about engineering opportunities at University of Delaware event

Share This